Partition coefficient and diffusion coefficient determinations of 50 compounds in human intact skin, isolated skin layers and isolated stratum corneum lipids
نویسندگان
چکیده
منابع مشابه
Characterization of skin friction coefficient, and relationship to stratum corneum hydration in a normal Chinese population.
BACKGROUND AND OBJECTIVES Studies have demonstrated that some cutaneous biophysical properties vary with age, gender and body sites. However, the characteristics of the skin friction coefficient in different genders and age groups have not yet been well established. In the present study, we assess the skin friction coefficient in a larger Chinese population. METHODS A total of 633 subjects (3...
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The skin is the largest organ of the body, whose main function is to protect the body against the loss of physiologically important components as well as harmful environmental insults. From the inside to the outside, the skin comprises three major structural layers: the hypodermis, the dermis and the epidermis. The epidermis contains four different sublayers, the stratum corneum (SC), stratum g...
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Under normal circumstances, epidermis must be as impermeable as possible except for a small amount of water loss to hydrate the outer layers of the SC. Although all living cells require water to function, some “dead” cells also require water to be metabolically active. As it is the case of corneocytes, epidermis must retain sufficient water to (a) hydrate the outer layers of the SC to maintain ...
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Ever since Ervin Blank discovered1 the importance of moisturizing the stratum corneum, companies have focused their attention on developing a better surface barrier or improving skin surface moisturization in the outer layers of the stratum corneum. More recently, agents such as peroxisomal proliferator-activated receptor (PPAR) ligands have been developed and exploited in moisturizers. These a...
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ژورنال
عنوان ژورنال: Toxicology in Vitro
سال: 2020
ISSN: 0887-2333
DOI: 10.1016/j.tiv.2020.104990